44Sc: An Attractive Isotope for Peptide-Based PET Imaging
نویسندگان
چکیده
منابع مشابه
44Sc: An Attractive Isotope for Peptide-Based PET Imaging
The overexpression of integrin αvβ3 has been linked to tumor aggressiveness and metastasis in several cancer types. Because of its high affinity, peptides containing the arginine-glycine-aspartic acid (RGD) motif have been proven valuable vectors for noninvasive imaging of integrin αvβ3 expression and for targeted radionuclide therapy. In this study, we aim to develop a (44)Sc-labeled RGD-based...
متن کاملSc: An Attractive Isotope for Peptide-Based PET Imaging
The overexpression of integrin αvβ3 has been linked to tumor aggressiveness and metastasis in several cancer types. Because of its high affinity, peptides containing the arginine−glycine−aspartic acid (RGD) motif have been proven valuable vectors for noninvasive imaging of integrin αvβ3 expression and for targeted radionuclide therapy. In this study, we aim to develop a Sc-labeled RGD-based pep...
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Peptides that target cancer cell surface receptors are promising platforms to deliver diagnostic and therapeutic payloads specifically to cancer but not normal tissue. IL13RA2 is a tumor-restricted receptor found to be present in several aggressive malignancies, including in the vast majority of high-grade gliomas and malignant melanoma. This receptor has been successfully targeted for diagnost...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2014
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp500343j